ABSTRACT
Objectives: Varenox is the first locally manufactured and approved biosimilar in Algeria. It is an enoxaparin sodium (ES) with established good analytical characterization and manufacturing quality control. The aim of the PROPHYVAR study was to generate real-life data in routine practices and to assess the safety and tolerability in the prophylaxis of venous thromboembolism (VTE). Method(s): This is an observational, prospective, multicenter study, conducted between April 2021 and May 2022. The primary safety outcome was the incidence of Adverse Events (AEs) related to the study drug. A sample size of 500 patients was calculated to estimate the proportion of patients with AEs. Assuming that approximately 10% will be lost to follow-up or not evaluable, 550 patients were needed to describe the impact of Varenox use. Result(s): The study was conducted in 25 different sites in Algeria, in 4 therapeutic areas: ICU, orthopedic surgery, obstetrics and nephrology;550 patients were included and received at least one injection of Varenox. The mean age was 47 years, women in majority (62.5%). The patients were overweight or obese (53%), with a history of arterial hypertension (25%), diabetes (7.5%) and renal failure (6.4%). Reasons for hospitalization were mainly fracture (15.5%), pregnancy (8.3%), COVID-19 (7%) or cancer (7%). The majority of patients were treated at prophylactic dose of 0.4ml (80%) or 0.6ml (10%). The median duration of follow-up was 24 days. A total of 38 patients experienced at least one AE (6.9%, CI95=[4.9%;9.4%]). Related AEs were reported in 10 patients (1.8%), mainly in nephrology (N=7 arterio-venous fistula). VTE events were reported in 6 patients (1.1%, CI95=[0.2%;2%]). Conclusion(s): This study suggests that Varenox is safe in the prophylaxis of VTE. To our knowledge this is the first large study describing the use of ES in current medical practice in Algeria.Copyright © 2023
ABSTRACT
The SARS-CoV-2 pandemic has led to over 4.9 million deaths as of October 2021. One of the main challenges of creating vaccines, treatment, or diagnostic tools for the virus is its mutations and emerging variants. A couple of variants were declared as more virulent and infectious than others. Some approaches were used as nomenclature for SARS-CoV-2 variants and lineages. One of the most used is the Pangolin nomenclature. In our study, we enrolled 35 confirmed SARS-CoV-2 patients and sequenced the viral RNA in their samples. We also aimed to highlight the hallmark mutations in the most frequent lineage. We identified a seven-mutation signature for the SARS-CoV-2 C36 lineage, detected in 56 countries and an emerging lineage in Egypt. In addition, we identified one mutation which was highly negatively correlated with the lineage. On the other hand, we found no significant correlation between our clinical outcomes and the C36 lineage. In conclusion, the C36 lineage is an emerging SARS-CoV-2 variant that needs more investigation regarding its clinical outcomes compared to other strains. Our study paves the way for easier diagnosis of variants of concern using mutation signatures.
ABSTRACT
To explore the effect of COVID-19 pandemic lockdown on vegetation cover changes in Northern, Middle, and Eastern Jordan Badia rangelands, Landsat-8 (Operational Land Imager [OLI]) images were downloaded and processed to attain surface reflectance data for March and July 2018–2020. Normalized difference vegetation index (NDVI) was then derived from OLI-images, where the total area covered with water, bare soil, scattered vegetation, dense grasses and shrubs, and dense forests were estimated. Across the study period, 2019 had the highest rainfall (195 mm) and temperature (21.7 °C), while the lowest rainfall was recorded in 2018 (154 mm). The Northern Badia showed a consistently larger area of dense vegetation on average (407.4 km2) compared to the Eastern (149.3km2), and Middle (55.2 km2) Badia. The total area covered with scattered vegetation in 2020 was higher than in 2019 and 2018 across the years and studied area, except in Middle Badia. Vegetation cover classes were inconsistent for Middle Badia in March, scattered vegetation was higher in 2019 compared to 2020. However, the total area covered with vegetation in July was lower than in March across the years and studied area. The curfew allowed the regeneration of shrubs and grasses in the study area, which helped in restoring the rangeland vegetation. COVID-19 lockdown served as a conservation grazing technique and provided a real case of restoring the degraded rangeland cover through managed grazing. [ABSTRACT FROM AUTHOR] Copyright of Arid Land Research & Management is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)